In this study, production and characterization of electrospun polyamide 6 (PA 6) nanofiber webs containing Mentha piperita L. extract, Pimpinella anisum L. extract, Syzygium aromaticum L. oil, and Papaver somniferum L. oil for the purpose of ache and pain relief were aimed. At the production stage herbal agents were added to the electrospinning solution and also agents were soaked on pure PA6 nanofiber webs. Nanofiber production was only not possible with P.somniferum oil. Besides, all other samples were succesfully produced. Morphological characterization was performed by scanning electron microscope (SEM) and optimum electrospinning process parameters were determined according to the SEM images for the production of uniform nanofibers. Long-term electrospinning was performed at these parameters for both pure PA6 nanofibers and herbal agent loaded PA6 nanofibers. Fourier Transform Infrared Spectrophotometer analysis was applied to these nanofiber webs and it was proved that the herbal agents loaded to fiber spinning solutions were successfully incorporated in nanofiber structures. Then, batch release tests were carried out where the isotonic solution was chosen as release medium. The UV-visible region spectrophotometer and high performance liquid chromatography analyses were applied to the fluids taken from the release media at determined time intervals and the release profiles of the nanofiber webs were determined.

Allover the results obtained from the study showed that herbal agents were succesfully incorporated to nanofiber structure and nanofiber webs that have potentials to be used as natural active agent release systems were achieved.

– This study is made by Eda Nebihe Solak