Orthognathic surgery includes invasive, major surgical procuders that are frequently performed to correct maxillofacial deformities. Since postoperative pain and oedema can significantly affect patient comfort after orthognathic surgery, many methods have been investigated for the management of the inflammatory process. Non-steroidal anti-inflammatory drugs, corticosteroids and opioid analgesics are used to control postoperative pain and oedema. Pre-emptive analgesia is a preferred method for managing postoperative pain caused by nociceptive and central stimulation.

The aim of this study was to investigate the effects of preemptive intravenous dexketoprofen trometamol administration on postoperative pain and oedema in orthognathic surgery.

This controlled clinical study was designed as a single centre, prospective, double-blind, randomized. Thirty patients that included in the study were randomly divided into two groups (n = 30). 50 mg / ml intravenous dexketoprofen trometamol were administrated 30 minutes before incision in patients group I (deksketoprofen trometamol n = 15) and intravenous sterile saline were administrated 30 minutes before incision in patients’ group II (placebo n = 15). Tramadol with patient-controlled analgesia were given for management of postoperative pain. Visual analogue scale was used to evaluate postoperative pain. 3dMD Face System (3dMD, ATLANTA, GA, USA) was used to measure postoperative swelling. There was a statistically significant decrease postoperative tramadol consumption and VAS scores in preemptive dexketoprofen group (p<0,05). There was no statistically significant difference between the groups in terms of oedema formation (p>0,05).

In conclusion, preemptive administration of intravenous dexketprophen provide adequate analgesia effect in the postoperative 24-hour period and reduce opioid consumption in orthognathic surgery.

– Study is made by Yusuf Nuri Kaba